abstract：BACKGROUND:Mycophenolate mofetil (MMF) has enjoyed increasing popularity as an emerging immunosuppressant treatment for various autoimmune dermatologic conditions, including pyoderma gangrenosum (PG). OBJECTIVE:The aim of this study was to examine the efficacy and safety of MMF as used in PG. METHODS:A retrospective ...

journal_title：Journal of the American Academy of Dermatology

authors： Li J,Kelly R

更新日期：2013-10-01 00:00:00

abstract：:Zinc is a trace element essential to the gastrointestinal, immune, integumentary, reproductive, and central nervous systems. Zinc deficiency is prevalent in many areas of the world and is a diagnostically challenging condition. Cutaneous manifestations typically occur in moderate to severe zinc deficiency and present ...

journal_title：Journal of the American Academy of Dermatology

authors： Corbo MD,Lam J

更新日期：2013-10-01 00:00:00

abstract：:Kawasaki disease, or mucocutaneous lymph node syndrome, is the leading cause of acquired heart disease in children in the United States and other developed countries. Coronary artery lesions are the most significant cause of morbidity and mortality. Treatment should ideally be provided within 10 days of symptom onset ...

journal_title：Journal of the American Academy of Dermatology

authors： Bayers S,Shulman ST,Paller AS

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. OBJECTIVE:We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. METHODS:Gene expression and protease activity were measured in laboratory mod...

journal_title：Journal of the American Academy of Dermatology

authors： Coda AB,Hata T,Miller J,Audish D,Kotol P,Two A,Shafiq F,Yamasaki K,Harper JC,Del Rosso JQ,Gallo RL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting. OBJECTIVE:In this study, we evaluate the specificity and sensitivity of p16 immunohistoc...

journal_title：Journal of the American Academy of Dermatology

authors： Kazlouskaya V,Shustef E,Allam SH,Lal K,Elston D

更新日期：2013-09-01 00:00:00

abstract：:"Poikiloderma" is a morphologic and descriptive term referring to a combination of cutaneous atrophy, telangiectasia, and varied macular pigmentary changes that result in a mottled skin appearance. Its etiology includes both congenital and acquired causes. Many studies have reported different causes of acquired poikil...

journal_title：Journal of the American Academy of Dermatology

authors： Nofal A,Salah E

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Ipilimumab is a human antibody that inhibits cytotoxic T-lymphocyte-associated antigen 4, leading to increases in T-cell activation and interleukin 2 secretion and has been approved for the treatment of advanced melanoma. Dermatologic adverse events such as rash, pruritus, and vitiligo have been reported in ...

journal_title：Journal of the American Academy of Dermatology

authors： Minkis K,Garden BC,Wu S,Pulitzer MP,Lacouture ME

更新日期：2013-09-01 00:00:00

abstract：:Skin toxicities are the most common side effects associated with the epidermal growth factor receptor inhibitor erlotinib, occurring in most patients receiving the drug. Clinical trials evaluating erlotinib for the treatment of non-small cell lung cancer have reported a range of skin disorders, the most common being a...

journal_title：Journal of the American Academy of Dermatology

authors： Kiyohara Y,Yamazaki N,Kishi A

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Some studies have purported to link isotretinoin prescribed for acne with the development of inflammatory bowel disease (IBD). OBJECTIVE:We sought to identify existence of disproportionate attorney-initiated reporting of isotretinoin-associated IBD in the Food and Drug Administration Adverse Event Reporting...

journal_title：Journal of the American Academy of Dermatology

authors： Stobaugh DJ,Deepak P,Ehrenpreis ED

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) has traditionally focused on minimizing recurrence and complication rates. However, the assessment of patient satisfaction and quality of life (QOL) is also important. These outcomes are best assessed by patient-reported outcome (PRO) ...

journal_title：Journal of the American Academy of Dermatology

authors： Lee EH,Klassen AF,Nehal KS,Cano SJ,Waters J,Pusic AL

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Lack of agreement on how to accurately capture disease outcomes in localized scleroderma (LS) has hindered the development of efficacious treatment protocols. The LS Cutaneous Assessment Tool (LoSCAT), consisting of the modified LS Skin Severity Index (mLoSSI) and the LS Damage Index, has potential for use i...

journal_title：Journal of the American Academy of Dermatology

authors： Kelsey CE,Torok KS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Photosensitivity (PS) in lupus erythematosus (LE) is frequently determined by patient report. OBJECTIVE:We sought to characterize self-reported PS in cutaneous LE (CLE). METHODS:The PS survey was used to classify subject responses into 5 phenotypes: direct sun-induced CLE flare (directCLE); general exacerb...

journal_title：Journal of the American Academy of Dermatology

authors： Foering K,Chang AY,Piette EW,Cucchiara A,Okawa J,Werth VP

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The lack of recommendations regarding dosing and administration, an undetermined risk of hypothalamic-pituitary-adrenal axis alteration, and the unknown effectiveness of intramuscular (IM) corticosteroid injection to treat dermatologic disease may be deterrents to use. OBJECTIVE:We sought to evaluate presen...

journal_title：Journal of the American Academy of Dermatology

authors： Reddy S,Ananthakrishnan S,Garg A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Recurrences after Mohs micrographic surgery (MMS) have been associated in the past with aggressive tumor type, large tumor size, and location within certain anatomic subunits. These factors are beyond the control of the treating physician and not subject to quality improvement efforts. OBJECTIVE:We sought t...

journal_title：Journal of the American Academy of Dermatology

authors： Campbell T,Armstrong AW,Schupp CW,Barr K,Eisen DB

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Differentiation between seborrheic keratosis (SK) and skin cancers may be difficult. Reflectance confocal microscopy (RCM) enables noninvasive assessment of skin neoplasms at cellular-level resolution. OBJECTIVE:We sought to describe RCM features of SK and to correlate these RCM findings with dermoscopic st...

journal_title：Journal of the American Academy of Dermatology

authors： Ahlgrimm-Siess V,Cao T,Oliviero M,Laimer M,Hofmann-Wellenhof R,Rabinovitz HS,Scope A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Clinical and histopathologic features of childhood melanoma are poorly characterized. Atypical clinical presentations and ambiguous microscopic findings may contribute to diagnostic delays. OBJECTIVES:We sought to determine whether conventional ABCDE melanoma detection criteria (Asymmetry, Border irregulari...

journal_title：Journal of the American Academy of Dermatology

authors： Cordoro KM,Gupta D,Frieden IJ,McCalmont T,Kashani-Sabet M

更新日期：2013-06-01 00:00:00

abstract：:When treating psoriasis, various topical emollients exist that can affect the penetration of ultraviolet radiation in phototherapy. Compared with normal-appearing skin with a reflectance of 4% to 5%, psoriatic skin has higher reflectance as a result of its increased air-to-corneocyte interfaces. Studies have tested th...

journal_title：Journal of the American Academy of Dermatology

authors： Asztalos ML,Heller MM,Lee ES,Koo J

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Australia has one of the highest rates of skin cancer globally. Lifetime risk is associated with childhood sun exposure. OBJECTIVE:We sought to investigate whether skin cancer prevention programs have resulted in improvements in sun-exposure and sun-protection behavior among young children in tropical Austr...

journal_title：Journal of the American Academy of Dermatology

authors： Smith A,Harrison S,Nowak M,Buettner P,Maclennan R

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES:We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS:Digi...

journal_title：Journal of the American Academy of Dermatology

authors： Pizzichetta MA,Talamini R,Marghoob AA,Soyer HP,Argenziano G,Bono R,Corradin MT,De Giorgi V,Gonzalez MA,Kolm I,Kopf AW,Malvehy J,Nami N,Oliviero M,Pellacani G,Puig S,Rabinovitz H,Rubegni P,Seidenari S,Stanganelli I,

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The Cutaneous Lupus Disease Area and Severity Index (CLASI) has not been validated using rheumatologist-conducted disease activity and damage assessments, especially cutaneous assessments. Active skin disease and skin damage may have substantial effects on patient-reported outcomes and on body image. OBJECT...

journal_title：Journal of the American Academy of Dermatology

authors： Jolly M,Kazmi N,Mikolaitis RA,Sequeira W,Block JA

更新日期：2013-04-01 00:00:00

abstract：:The great diversity of wounds and the broad range of available dressings complicate the selection of proper chronic wound treatment. Choosing the right treatment is the essential step in the healing process. In this review, we focus on chronic nonhealing ulcers, which are a critical problem in clinical practice, and c...

journal_title：Journal of the American Academy of Dermatology

authors： Skórkowska-Telichowska K,Czemplik M,Kulma A,Szopa J

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Onychomycosis is a common nail infection, often resulting in nail plate damage and deformity. Topical lacquer treatments have negligible efficacy. Oral treatments, although more efficacious, are limited by drug interactions and potential hepatotoxicity. OBJECTIVE:We investigated the safety and efficacy of e...

journal_title：Journal of the American Academy of Dermatology

authors： Elewski BE,Rich P,Pollak R,Pariser DM,Watanabe S,Senda H,Ieda C,Smith K,Pillai R,Ramakrishna T,Olin JT

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC). OBJECTIVE:We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment. METHODS:A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC betwee...

journal_title：Journal of the American Academy of Dermatology

authors： Tarantola TI,Vallow LA,Halyard MY,Weenig RH,Warschaw KE,Weaver AL,Roenigk RK,Brewer JD,Otley CC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Detection of melanoma by physicians via opportunistic surveillance during focused physical examinations may reduce mortality. Medical students may not encounter a clinical case of melanoma during a dermatology clerkship. OBJECTIVE:This study examined the proficiency of fourth-year University of Illinois at ...

journal_title：Journal of the American Academy of Dermatology

authors： Hernandez C,Mermelstein R,Robinson JK,Yudkowsky R

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown. OBJECTIVE:We sought to investigate the...

journal_title：Journal of the American Academy of Dermatology

authors： Chen YC,Chang CY,Cho YT,Chiu HC,Chu CY

更新日期：2013-03-01 00:00:00

abstract：:Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis di...

journal_title：Journal of the American Academy of Dermatology

authors： Shah KR,Boland CR,Patel M,Thrash B,Menter A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Treatment guidelines are lacking for classic Kaposi sarcoma. OBJECTIVE:We sought to review the evidence on efficacy of treatments for classic Kaposi sarcoma. METHODS:Articles published in English or French in MEDLINE, Trip, Cochrane Library, and Pascal databases from 1980 to December 2010 were screened. St...

journal_title：Journal of the American Academy of Dermatology

authors： Régnier-Rosencher E,Guillot B,Dupin N

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Degos disease or malignant atrophic papulosis is a rare occlusive vasculopathic disease characterized by pathognomonic cutaneous lesions and frequently fatal systemic involvement. The etiology of malignant atrophic papulosis remains unclear, and there is currently no effective treatment for malignant atrophi...

journal_title：Journal of the American Academy of Dermatology

authors： Meephansan J,Komine M,Hosoda S,Tsuda H,Karakawa M,Murata S,Demitsu T,Ohtsuki M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Epidermolysis bullosa (EB) is a genetic, heterogeneous, trauma-induced blistering disease. Patients with laminin-332-deficient non-Herlitz junctional EB (JEB-nH) can have impaired wound healing witnessed by persistent, small, deep ulcers on the hands and feet that adversely affect the quality of life. OBJEC...

journal_title：Journal of the American Academy of Dermatology

authors： Yuen WY,Huizinga J,Jonkman MF

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Port-wine stains (PWS) may thicken and darken with age. Little is known about the pathogenesis and epidemiology of PWS hypertrophy because of the lack of large studies. OBJECTIVE:We sought to assess the prevalence and characteristics of patients with hypertrophic PWS. METHODS:Medical records and clinical p...

journal_title：Journal of the American Academy of Dermatology

authors： van Drooge AM,Beek JF,van der Veen JP,van der Horst CM,Wolkerstorfer A

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Giant angiofibromas in patients with tuberous sclerosis complex (TSC) are rare. OBJECTIVE:We sought to report two patients who had TSC with unusually large and disfiguring facial angiofibromas and to identify underlying histopathologic changes that may possibly explain the clinical features. METHODS:We per...

journal_title：Journal of the American Academy of Dermatology

authors： Kacerovska D,Kerl K,Michal M,Filipova H,Vrtel R,Vanecek T,Zelenakova H,Kraus J,Kodet R,Kazakov DV

更新日期：2012-12-01 00:00:00

abstract：:Collodion baby is an uncommon clinical presentation of several genetic conditions, primarily disorders of cornification. The severely compromised epidermal barrier presents the greatest challenge during the newborn period and advances in neonatal care have significantly improved the prognosis. This review summarizes t...

journal_title：Journal of the American Academy of Dermatology

authors： Prado R,Ellis LZ,Gamble R,Funk T,Arbuckle HA,Bruckner AL

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Genetic and environmental components may contribute to acne causation. OBJECTIVE:We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne. METHODS:We conducted a case-control study in dermatologic outpatient clin...

journal_title：Journal of the American Academy of Dermatology

authors： Di Landro A,Cazzaniga S,Parazzini F,Ingordo V,Cusano F,Atzori L,Cutrì FT,Musumeci ML,Zinetti C,Pezzarossa E,Bettoli V,Caproni M,Lo Scocco G,Bonci A,Bencini P,Naldi L,GISED Acne Study Group.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Teledermatology programs in the United States have evolved over the past several decades. No systematic survey of teledermatology programs in the United States is available in peer-reviewed literature. OBJECTIVE:To provide up-to-date information regarding the state of teledermatology programs in the United ...

journal_title：Journal of the American Academy of Dermatology

authors： Armstrong AW,Wu J,Kovarik CL,Goldyne ME,Oh DH,McKoy KC,Shippy AM,Pak HS

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Sox10 is a transcription factor associated with neural crest development. Its expression has been reported in melanocytes and peripheral nerve sheath cells and their associated tumors. OBJECTIVE:To assess Sox10 sensitivity in benign and malignant melanocytic neoplasms of various histologic subtypes and to d...

journal_title：Journal of the American Academy of Dermatology

authors： Shin J,Vincent JG,Cuda JD,Xu H,Kang S,Kim J,Taube JM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Ultraviolet (UV) photography has been used to motivate sun safety in behavioral interventions. The relationship between sun damage shown in UV photographs and melanoma risk has not been systematically investigated. OBJECTIVE:To examine the relationship between severity of sun damage in UV photographs and ph...

journal_title：Journal of the American Academy of Dermatology

authors： Gamble RG,Asdigian NL,Aalborg J,Gonzalez V,Box NF,Huff LS,Barón AE,Morelli JG,Mokrohisky ST,Crane LA,Dellavalle RP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Pachyonychia congenita (PC) is a group of autosomal dominant keratinizing disorders caused by a mutation in one of 4 keratin genes. Previous classification schemes have relied on data from case series and case reports. Most patients in these reports were not genetically tested for PC. OBJECTIVE:We sought to...

journal_title：Journal of the American Academy of Dermatology

authors： Eliason MJ,Leachman SA,Feng BJ,Schwartz ME,Hansen CD

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Non-adherence rates are high among patients with psoriasis, partly because of discordance between recommended treatments and individual preferences. OBJECTIVES:Our aim was to assess the impact of comorbidities on patients' preferences for psoriasis treatments. METHODS:A computer-based conjoint analysis exp...

journal_title：Journal of the American Academy of Dermatology

authors： Schmieder A,Schaarschmidt ML,Umar N,Terris DD,Goebeler M,Goerdt S,Peitsch WK

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Vulvo-cervico-vaginal involvement has rarely been reported in pemphigus vulgaris (PV) and has not been reported in pemphigus foliaceus (PF). OBJECTIVES:We sought to evaluate genital lesions and Papanicolaou (Pap) smears in female patients with PV and PF. METHODS:This prospective study includes all consecut...

journal_title：Journal of the American Academy of Dermatology

authors： Fairbanks Barbosa ND,de Aguiar LM,Maruta CW,Aoki V,Sotto MN,Labinas GH,Perigo AM,Santi CG

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Among the papular-pruriginous dermatoses related to human immunodeficiency (HIV) infection, two entities remain poorly differentiated leading to confusion in their diagnosis: HIV-related pruritic papular eruption (HIV-PPE or prurigo) and eosinophilic folliculitis (HIV-EF). OBJECTIVE:To establish histopathol...

journal_title：Journal of the American Academy of Dermatology

authors： Afonso JP,Tomimori J,Michalany NS,Nonogaki S,Porro AM

更新日期：2012-08-01 00:00:00